Conformation of membrane-inserted P-glycoprotein

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Conformation of membrane-inserted P-glycoprotein

Background The human genome codes for 49 members of the large ABC protein family. Most of them are membrane transporters. The first structures of exporters have been solved in recent years. Although a remarkable achievement, some uncertainty remained with respect to the physiological conformation of the transporter, which seems not to be fully compatible with all biochemical evidence. During cr...

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ژورنال

عنوان ژورنال: BMC Pharmacology

سال: 2010

ISSN: 1471-2210

DOI: 10.1186/1471-2210-10-s1-a27